菌血症或念珠菌血症的脓毒症患者病原菌和感

Influenceofpathogenandfocusofinfectiononprocalcitoninvaluesinsepsispatientswithbacteremiaorcandidemia

菌血症或念珠菌血症的脓毒症患者病原菌和感染灶对降钙素原值的影响

INTRODUCTION

Thisstudyaimedtoevaluatetheaccuracyofprocalcitonin(PCT)serumconcentrationstodiagnoseGram-negativebacteremiaandtheassociationofPCTserumconcentrationswithmorespecificpathogensandthefocusofinfection.

研究背景：本研究旨在评估降钙素原（PCT）血清浓度诊断革兰氏阴性菌血症的准确性以及PCT血清浓度与更具体的病原体和感染灶的关系。

METHOD

Secondaryanalysisoftheprospectivelycollectedpatient-leveldatasetfromaclusterrandomizedqualityimprovementtrialwasperformed.Thetrialincludedsepsispatientswithorgandysfunctiontreatedintheparticipatingintensivecareunitsfromto.TestperformanceforthepredictionofGram-negativebacteremiawasassessedbyreceiveroperatingcurveanalysis.IndependenteffectsofspecificpathogengroupsandfociofinfectiononPCTconcentrationswereassessedbylinearlogisticregressionmodels.

研究方法：对来自集群随机质量改进试验的前瞻性收集的患者水平数据集进行二次分析。该试验包括年至年重症监护病房治疗的脓毒症器官功能障碍患者。通过受试者操作曲线分析评估预测革兰氏阴性菌血症的测试表现。通过线性逻辑回归模型评估特定病原体组和感染病灶对PCT浓度的独立影响。

RESULTS

Bloodcultures(BC)andPCTconcentrationshadbeentakeninofdocumentedpatients.PCTwassignificantlyhigherinGram-negativebacteremia